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Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...

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Related Experiment Video

Updated: May 9, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem

Sayed Chandini1, Debangana Dey1, Tina Gulati2

  • 1Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Sector-125, Noida, Uttar Pradesh, 201303, India.

Molecular Neurobiology
|May 8, 2026
PubMed
Summary
This summary is machine-generated.

Metabolism and micronutrients are crucial regulators of central nervous system (CNS) development, influencing neural stem cell (NSC) proliferation, differentiation, and function. Understanding these processes offers new therapeutic avenues for neurological disorders.

Keywords:
MetabolismMicronutrientsMitochondriaNSCNutraceuticalOne carbon metabolismVitamin BVitamin D

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Related Experiment Videos

Last Updated: May 9, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Central nervous system (CNS) development relies on neural stem cells (NSCs) undergoing regulated division and differentiation.
  • Metabolism and external factors, such as micronutrients, significantly influence NSC behavior and neurodevelopmental outcomes.

Purpose of the Study:

  • To review recent insights into how metabolism and micronutrients regulate neurodevelopmental events.
  • To highlight the role of mitochondria in NSC fate and function.
  • To explore the therapeutic potential of nutraceuticals in neurological disorders.

Main Methods:

  • Literature review focusing on metabolism, micronutrients, and neural stem cells.
  • Analysis of recent studies on mitochondrial function in neurodevelopment.
  • Examination of the interplay between metabolism, epigenetics, and NSC differentiation.

Main Results:

  • Metabolism acts as a key integrator of external signals affecting NSC proliferation, fate determination, and differentiation.
  • Micronutrients profoundly impact neurodevelopmental stages, including migration and maturation.
  • Mitochondria are central to NSC fate and functionality, and metabolism orchestrates the NSC epigenome.

Conclusions:

  • Metabolism and micronutrients are critical regulators of neurodevelopment.
  • Mitochondrial function and metabolic pathways are key targets for understanding and treating neurological disorders.
  • Nutraceuticals show promise for mitigating risks associated with neurodevelopmental and adult neurological conditions.