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Related Experiment Video

Updated: May 9, 2026

Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements

Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements

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Medication Samples and Smoking Cessation Among Adults: A Randomized Clinical Trial.

Matthew J Carpenter^1,2, Tracy T Smith^1,2, Amy E Wahlquist³

¹Hollings Cancer Center, Medical University of South Carolina (MUSC), Charleston.

JAMA Network Open

|May 8, 2026

Summary

Varenicline sampling significantly increased smoking cessation rates compared to no-sampling controls and nicotine replacement therapy (NRT). This medication sampling approach shows promise for engaging adults who smoke (AWS) in quitting efforts.

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Published on: August 6, 2013

Area of Science:

Public Health
Clinical Trials
Pharmacology

Background:

Smoking cessation interventions need to be brief, concrete, and valid for scalability.
Medication sampling is a potential strategy to improve intervention reach among adults who smoke (AWS).

Purpose of the Study:

To determine the outcomes of varenicline sampling in a randomized clinical trial (RCT) for adults who smoke.
To compare varenicline sampling with nicotine replacement therapy (NRT) and quitline referral.

Main Methods:

A decentralized RCT involving 651 non-treatment seeking AWS in South Carolina.
Participants were randomized to receive 4-week samples of varenicline, NRT (active control), or quitline referral (inactive control).
Primary outcome was self-reported 7-day point prevalence abstinence (PPA) at 6-month follow-up.

Main Results:

Varenicline sampling led to higher self-reported PPA (17% vs 10%) and floating abstinence (34% vs 20%) compared to the no-sampling control.
Varenicline sampling was superior to NRT for 6-month self-reported abstinence (17% vs 8%) and reduction in cigarettes per day (CPD) at week 8.
No significant difference in carbon monoxide (CO)-verified abstinence at 6 months between varenicline and no-sampling control.

Conclusions:

Varenicline sampling is an efficacious strategy for smoking cessation in adults who smoke.
Medication sampling offers a pragmatic approach to engage AWS in quitting, with potentially superior outcomes to NRT.
Further evaluation of medication sampling in applied settings is warranted.