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Nucleophiles as Reaction Switches: Dearomative Multifunctionalization of Isoquinoliniums to Rigid Bridged-Ring
Zerong Guo1, Yunlong Qin1, Qingling Wu1
1College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, P. R. China.
None:
We report a dearomative multifunctionalization strategy that converts planar isoquinoliniums into three-dimensional, sp3-rich bridged bis-tetrahydroisoquinolines. Nucleophiles serve dual roles as reaction switches and stereodefined bridging linkers, enabling precise regio-, chemo-, and stereocontrol. This streamlined approach unlocks the full reactive potential of isoquinolines for constructing architecturally complex polycyclic frameworks with broad applicability to carbon-, nitrogen-, and sulfur-centered nucleophiles. PMI analysis and physicochemical evaluation confirm their pronounced three-dimensionality and drug-like profiles.
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