Related Experiment Video

Updated: May 10, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Candida glabrata and the host: a neglected affair

Manisha Ghosh1,2, Mayur Raney1,3, Rupinder Kaur1

  • 1BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, 500039, Telangana, India.

Journal of Medical Microbiology
|May 8, 2026
PubMed

Insights

Candida glabrata, a high-priority fungal pathogen, causes invasive infections and drug resistance. Understanding its interaction with host cells is crucial for managing infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Host-Pathogen Interactions

Background:

  • Candida glabrata (Nakaseomyces glabratus) is a major opportunistic human pathogen.
  • It is a leading cause of invasive Candida infections, particularly in hospitalized and immunocompromised individuals.
  • C. glabrata exhibits co-resistance to azole and echinocandin drugs and lacks typical virulence factors like filamentation.

Purpose of the Study:

  • To review the interplay between Candida glabrata and various host cell types.
  • To outline molecular strategies employed by C. glabrata during infection.
  • To highlight knowledge gaps in C. glabrata-host interactions for improved infection management.

Main Methods:

  • Literature review of studies on Candida glabrata-host cell interactions.
  • Analysis of molecular mechanisms contributing to C. glabrata virulence.
  • Synthesis of current understanding of host-pathogen crosstalk.

Main Results:

  • C. glabrata possesses unique virulence attributes distinct from other Candida species.
  • Its ability to evade strong host inflammatory responses aids persistence.
  • The molecular basis of C. glabrata's success in host environments remains incompletely understood.

Conclusions:

  • Further research into C. glabrata-host crosstalk is essential.
  • Understanding these interactions will guide the development of effective therapeutic strategies.
  • Addressing knowledge gaps is vital for combating C. glabrata infections.
Keywords:
chromatin architecturegenome evolutionhost–pathogen dynamicshuman fungal pathogensinnate immune systemmetabolism reprogramming

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