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Pyroptosis Regulated by N6-Methyladenosine Modification: Implications for Pyroptosis-Related Disease Therapy

Yujun Zhou1, Bo Wei2, Sihan Chen2

  • 1Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, China.

Journal of Innate Immunity
|May 8, 2026
PubMed
Abstract

Insights

Pyroptosis, a programmed cell death, is regulated by N6-methyladenosine (m6A) modification. Understanding this epigenetic link offers new therapeutic strategies for inflammatory diseases and cancer.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Immunology

Background:

  • Pyroptosis is a lytic, inflammatory programmed cell death pathway crucial for host defense but implicated in various diseases when dysregulated.
  • N6-methyladenosine (m6A) is a prevalent RNA epigenetic modification impacting gene expression from RNA processing to protein synthesis.

Purpose of the Study:

  • To systematically review signaling pathways regulating pyroptosis.
  • To comprehensively analyze the dynamic regulation of pyroptosis by m6A modification.
  • To explore the pathophysiological significance of m6A-mediated pyroptosis in disease and identify therapeutic targets.

Main Methods:

  • Literature review of signaling pathways involved in pyroptosis.
  • Analysis of the role of m6A 'writer', 'eraser', and 'reader' proteins in pyroptosis.
  • Examination of the link between m6A-regulated pyroptosis and disease progression.

Main Results:

  • Pyroptosis is executed by gasdermin proteins following inflammasome activation, leading to cell lysis and inflammation.
  • m6A modification dynamically influences pyroptosis through specific regulatory proteins.
  • Aberrant pyroptosis is linked to sepsis, inflammatory disorders, cancer, atherosclerosis, and neurodegenerative diseases.

Conclusions:

  • m6A modification represents a key regulatory mechanism in pyroptosis.
  • Targeting m6A-mediated pyroptosis pathways presents promising therapeutic avenues for pyroptosis-related diseases.
  • Further research into m6A-regulated pyroptosis can uncover novel therapeutic targets for inflammatory and other pathologies.
Keywords:
CancerGasdermin DInflammationMethyltransferase-like 3N6-methyladenosine modificationNLRP3Pyroptosis

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