Mapping the Research Landscape and Emerging Trends in Hashimoto's Encephalopathy: A CiteSpace-Based Visualization...

Area of Science:

• Neurology
• Endocrinology
• Bibliometrics

Background:

• Hashimoto's thyroiditis is a primary cause of hypothyroidism, frequently associated with other conditions.
• Hashimoto's encephalopathy (HE) is a severe neurological complication of Hashimoto's thyroiditis.
• Understanding HE research trends is crucial for clinical management and scientific advancement.

Purpose of the Study:

• To comprehensively analyze global research trends in Hashimoto's encephalopathy (HE).
• To identify key authors, institutions, journals, and research hotspots in HE.
• To provide insights into the evolution of HE research from 1990 to 2025.

Main Methods:

• Bibliometric analysis of publications on HE retrieved from the Web of Science Core Collection (1990-2025).
• Utilized CiteSpace software for data analysis.
• Examined publication volume, author contributions, institutional affiliations, journal impact, and keyword co-occurrence.

Main Results:

• A total of 641 publications on HE were identified from 65 countries.
• The United States leads in publication volume, with the Mayo Clinic as a leading institution.
• Current research focuses on clinical manifestations, diagnostic criteria, and serological biomarkers like anti-α-enolase antibodies.

Conclusions:

• Research efforts aim to improve the characterization and diagnostic accuracy of HE.
• Emerging technologies (advanced imaging, omics, machine learning) show promise for early detection and precise diagnosis.
• Advancements in understanding HE could lead to improved patient outcomes.