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Updated: May 10, 2026
12:23
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
Association Between Pan-Immune-Inflammation Value and Mortality in Osteoarthritis: Evidence for Elevated Risk at
Donghai Wang1,2, Fang Li2, Yantong Liu1
1Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Modern Rheumatology
|May 8, 2026
Summary
The pan-immune-inflammation value (PIV) is linked to higher mortality in osteoarthritis patients. Higher PIV indicates an increased risk of death from all causes and cardiovascular disease in adults with OA.
Area of Science:
- Rheumatology
- Cardiovascular Disease
- Inflammation Research
Background:
- Systemic inflammation is a key factor in osteoarthritis (OA) progression.
- The pan-immune-inflammation value (PIV) is an emerging marker for systemic inflammation.
Purpose of the Study:
- To investigate the association between PIV and mortality in patients with OA.
- To explore the relationship between PIV and both all-cause and cardiovascular disease (CVD) mortality.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (1999-2018).
- Calculated PIV using platelet, neutrophil, monocyte, and lymphocyte counts.
- Assessed OA via self-report and mortality through the National Death Index.
Main Results:
- A total of 3903 OA participants were analyzed.
- Higher PIV levels were significantly associated with increased all-cause and CVD mortality.
- A threshold effect was observed, with significant associations appearing after an inflection point.
Conclusions:
- Elevated PIV is associated with greater mortality risk in US adults with OA.
- Further research is required to determine PIV's utility in clinical mortality prediction models.
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