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Contusion Spinal Cord Injury via a Microsurgical Laminectomy in the Regenerative Axolotl
Published on: October 20, 2019
The brain-limb axis: Elucidating CNS mediators of salamander limb regeneration
Noah Lopez1, S Y Celeste Wu1, Jessica L Whited1
1Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA, 02138, USA.
Abstract:
Salamanders have the remarkable ability of regenerating complex tissues such as their limbs, brain, and spinal cord. While the requirement of nerve supply to the damaged tissue has been known for centuries, emerging work has emphasized the possibility of a "brain-limb" axis, in which signals from the brain and spinal cord assist in coordinating local responses to injury. Understanding the molecular underpinnings of how regeneration is coordinated on a body-wide scale may provide further insights into how complex vertebrate regeneration is achieved.
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