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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: May 10, 2026

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

Advancing hepatocyte-based therapies: A translational perspective.

Zhen Sun1, Ludi Zhang1, Lijian Hui2

  • 1Laboratory of Liver Molecular Pathology, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

Cell Stem Cell
|May 8, 2026
PubMed
Summary

Hepatocyte-based therapies offer a promising alternative to liver transplantation, addressing cell availability and engraftment challenges. Further research is needed for scalable manufacturing and immune compatibility to enable clinical translation.

Keywords:
hepatocyte productionhepatocyte-based cell therapiesliver regenerative medicinetranslational perspective

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Last Updated: May 10, 2026

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Translational Research

Background:

  • Hepatocyte-based therapies show promise as an alternative to liver transplantation.
  • Clinical translation is hindered by limited functional cell supply and poor engraftment.

Purpose of the Study:

  • To review progress in hepatocyte-based therapies from a translational viewpoint.
  • To identify strategies for overcoming key challenges in clinical translation.
  • To assess emerging cell sources and clinical paradigms.

Main Methods:

  • Review of scientific literature on hepatocyte-based therapies.
  • Analysis of stem cell-derived sources and their therapeutic potential.
  • Organization of translational efforts around two clinical paradigms: replacement and support.

Main Results:

  • Emerging stem cell technologies offer new cell sources.
  • Two main clinical paradigms identified: long-term functional correction and temporary support for liver failure.
  • Preclinical advances include other liver cell types beyond hepatocytes.

Conclusions:

  • Critical gaps for clinical translation include scalable GMP manufacturing and efficient preconditioning.
  • Long-term immune compatibility, non-invasive graft monitoring, and patient stratification are essential.
  • Hepatocyte therapies can complement gene/RNA therapies and xenotransplantation for broader liver disease treatment options.