Related Experiment Video
Updated: May 10, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Tertiary lymphoid structures in head and neck squamous cell carcinoma as predictors of response to immunotherapy
Cara Griffin1, Meg L Donovan2, Clara Lawler3
1Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane QLD, Australia; Princess Alexandra Hospital, Brisbane QLD, Australia.
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is the seventh most prevalent cancer diagnosed in Australia, accounting for significant morbidity and mortality. Locoregional recurrence occurs in approximately half of HNSCC patients. Immunotherapy response rates in HNSCC remain modest at 20-35%. Therefore, it is essential to review and build on the evidence around how immunotherapy response is shaped by the tumour microenvironment (TME). Tertiary lymphoid structures (TLS) are emerging as predictors of immunotherapy response. This review summarises recent studies on TLS in HNSCC and investigates whether these have potential as predictive biomarkers.
Related Concept Videos
Tumor Immunotherapy
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
