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Pyelonephritis. 18. Effect of treatment on the pathology of enterococcal pyelonephritis in the rat
Abstract:
The effect of antimicrobial therapy on the histopathologic progression of experimental hematogenous pyelonephritis induced in rats by Streptococcus faecalis was studied. Treatment sufficient to render the renal parenchyma sterile strikingly decreased the incidence and severity of calyceal lesions, delayed the progression of papillary lesions but had little effect on the severity of cortical interstitial and tubular alterations. L-forms could not be demonstrated to participate in the pathogenesis of these lesions. Kanamycin had an independent nephrotoxic effect which complicated interpretation of the effect of therapy in animals receiving this agent.
Insights
Antimicrobial therapy significantly reduced kidney lesions in experimental pyelonephritis, but did not fully prevent cortical damage. L-forms were not implicated, and kanamycin showed nephrotoxicity.
Area of Science:
- Nephrology
- Infectious Diseases
- Pathology
Background:
- Hematogenous pyelonephritis is a serious kidney infection.
- Streptococcus faecalis is a causative agent.
- Understanding treatment effects on kidney pathology is crucial.
Purpose of the Study:
- To investigate the impact of antimicrobial therapy on histopathologic changes in experimental pyelonephritis.
- To assess the role of L-forms in disease progression.
- To evaluate the specific effects of kanamycin.
Main Methods:
- Induction of experimental hematogenous pyelonephritis in rats using Streptococcus faecalis.
- Administration of antimicrobial therapy to achieve renal parenchyma sterility.
- Histopathologic examination of renal tissues to assess calyceal, papillary, cortical interstitial, and tubular lesions.
- Investigation for the presence of L-forms.
- Assessment of kanamycin's nephrotoxic effects.
Main Results:
- Therapy significantly reduced the incidence and severity of calyceal lesions.
- Antimicrobial treatment delayed the progression of papillary lesions.
- Cortical interstitial and tubular alterations were minimally affected by the therapy.
- L-forms were not found to be involved in lesion pathogenesis.
- Kanamycin exhibited independent nephrotoxicity, complicating treatment effect interpretation.
Conclusions:
- Antimicrobial therapy effectively reduces upper urinary tract damage in experimental pyelonephritis.
- Therapy has limited impact on established cortical and tubular damage.
- L-forms do not appear to play a significant role in this model.
- Kanamycin's nephrotoxicity requires careful consideration in treatment strategies.