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Updated: May 10, 2026

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Extracellular vesicles: Whisperers of tumor immune evasion
An Hendrix1, Olivier De Wever1
1Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium.
Abstract:
Cancer stem cells (CSCs) shape immunosuppressive tumor microenvironments through diverse mechanisms. In this issue of Cancer Cell, Fan et al. demonstrate that CSC-derived extracellular vesicles promote regulatory T cell expansion and facilitate immune evasion. The mechanistic details reveal a therapeutic vulnerability that enhances responses to checkpoint blockade.
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