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Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

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Thread- reinforced encapsulation devices (THRED) for therapeutic stem cell delivery.

Fikir M Mesfin¹, Jasmine Lee¹, Sharon Joseph¹

¹Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.

Journal of Pediatric Surgery

|May 8, 2026

Summary

Encapsulating mesenchymal stem cells (MSCs) in the THRED device improved outcomes in a mouse model of intestinal injury. This delivery method shows promise for MSC-based therapies, addressing concerns about cell survival and efficacy.

Keywords:

Cell encapsulation Ischemia-reperfusion injury Mesenchymal stem cells

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Last Updated: May 10, 2026

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Published on: February 7, 2018

Area of Science:

Regenerative Medicine
Biomaterials Science
Gastroenterology

Background:

Mesenchymal stem cells (MSCs) show therapeutic potential but face challenges like limited longevity and tumorigenicity.
Immune rejection and poor survival hinder widespread clinical application of MSCs.
Developing effective delivery systems is crucial for harnessing MSC therapeutic benefits, especially for conditions like intestinal ischemic diseases.

Purpose of the Study:

To evaluate an encapsulation and delivery method for mesenchymal stem cells (MSCs).
To assess the therapeutic potential of encapsulated MSCs for treating intestinal ischemic diseases.

Main Methods:

Human vertebra bone adherent MSCs (vBA-MSCs) were encapsulated in an alginate-derived Thread Reinforced Encapsulation Device (THRED).
Encapsulated vBA-MSCs were assessed for viability, surface marker expression, and cytokine production.
The therapeutic efficacy of encapsulated MSCs was tested in a mouse model of intestinal ischemia-reperfusion injury.

Main Results:

Successful encapsulation of vBA-MSCs within the THRED device was achieved.
Encapsulated MSCs maintained viability, functionality, and characteristic cell surface markers.
Treatment with encapsulated MSCs significantly improved intestinal injury scores in the mouse model.

Conclusions:

The THRED device represents a viable strategy for delivering MSCs in therapeutic applications.
Further research is required to optimize cell dosage and delivery duration for maximal therapeutic benefit.