Related Experiment Video
Updated: May 10, 2026

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures
Published on: May 31, 2024
Supercooled liquid state facilitates recrystallization-mediated gelation of amorphous cinnarizine
Yutong Li1, Manlin Teng1, Sining Han1
1Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, China.
Abstract:
Amorphization is an effective strategy for enhancing the solubility of poorly water-soluble drugs. However, its benefits can be compromised by gelation-a counterintuitive phenomenon that leads to decreased dissolution behavior compared to the crystalline counterpart. In this study, we found that amorphous cinnarizine (CIN) exhibits a pronounced gelation tendency at higher pH, temperature, and ionic strength. We propose that the gelation process is initiated by CIN's transition into a supercooled liquid state above its glass transition temperature (Tg). This state is characterized by high viscosity but sufficient molecular mobility, which collectively facilitates rapid recrystallization and subsequent gel network formation. This study elucidates the underlying mechanism and offers a perspective for preventing gelation in low-Tg amorphous drugs.
Related Concept Videos
Recrystallization: Solid–Solution Equilibria
Crystal Growth: Principles of Crystallization
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent – the...
Colloidal precipitates
Polymer Classification: Crystallinity
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Precipitation Processes
Phase Transitions: Melting and Freezing

