Related Experiment Video

Updated: May 10, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Next-generation gene editing strategies in cancer: Integrating CRISPR, PROTACs, and advanced molecular technologies

Akash Vikal1, Rashmi Maurya2, Pradeep Kumar3

  • 1Sahu Onkar Saran School of Pharmacy, Faculty of Pharmacy, IFTM University, Moradabad, India.

Life Sciences
|May 8, 2026
PubMed

Insights

Genome editing and targeted protein degradation, including CRISPR and PROTACs, offer new cancer treatment strategies by correcting genes and removing proteins. Challenges remain, but nanotechnology, AI, and personalized medicine promise improved clinical translation.

Area of Science:

  • Oncology
  • Biotechnology
  • Genetics

Background:

  • Cancer presents significant therapeutic challenges due to tumor heterogeneity, multidrug resistance, and undruggable oncogenic drivers.
  • Precision oncology requires innovative approaches for genetic and proteomic interventions.

Purpose of the Study:

  • To explore the transformative potential of genome editing and targeted protein degradation in cancer therapy.
  • To highlight the synergistic possibilities of combining CRISPR-based systems and proteolysis-targeting chimeras (PROTACs).

Main Methods:

  • Utilizing CRISPR-based systems for gene correction.
  • Employing proteolysis-targeting chimeras (PROTACs) for selective protein removal.
  • Investigating the combined application of these technologies for cancer treatment.

Main Results:

  • The combination of genome editing and targeted protein degradation offers novel possibilities for long-lasting and specific cancer treatment.
  • These approaches facilitate the discovery of new therapeutic targets.
  • Delivery, off-target effects, and safety are identified challenges.

Conclusions:

  • Advancements in nanotechnology, artificial intelligence (AI), and personalized medicine are expected to enhance clinical translation.
  • The integration of these cutting-edge technologies represents a significant trend in next-generation cancer treatment.
Keywords:
Base and prime editingCRISPR-Cas systemsCancer therapyPROTACsPrecision oncologyTargeted protein degradation

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