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Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of the heart's...
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Updated: May 10, 2026

Intracranial Injection of Adeno-associated Viral Vectors
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Published on: November 17, 2010

Amiodarone-induced aseptic meningitis.

Lise Janssens1,2, Wendy Van Daele3, Katlijn Schotsmans3

  • 1Department of Neurology, Algemeen ziekenhuis ZAS Middelheim Neurologie, Antwerp, Belgium lise.janssens@vub.be.

BMJ Case Reports
|May 8, 2026
PubMed
Summary

Drug-induced aseptic meningitis (DIAM) is a rare adverse drug reaction. This case report highlights amiodarone as a potential new cause of DIAM, with symptoms resolving after medication withdrawal.

Keywords:
Drug interactionsDrugs: CNS (not psychiatric)Headache (including migraines)

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Published on: September 24, 2021

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Last Updated: May 10, 2026

Intracranial Injection of Adeno-associated Viral Vectors
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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
08:56

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Published on: September 24, 2021

Area of Science:

  • Pharmacology
  • Neurology
  • Clinical Medicine

Background:

  • Drug-induced aseptic meningitis (DIAM) is a rare but serious adverse drug reaction.
  • Various medications, including NSAIDs, IVIG, antibiotics, vaccines, and monoclonal antibodies, are associated with DIAM.
  • Amiodarone, a common anti-arrhythmic, is known for neurotoxic effects like tremor and peripheral neuropathy.

Purpose of the Study:

  • To report the first known case of aseptic meningitis induced by amiodarone.
  • To increase awareness of amiodarone as a potential cause of DIAM.

Main Methods:

  • Case presentation of a male patient in his late 70s.
  • Clinical evaluation including a 5-week history of headache, vomiting, and weight loss.
  • Cerebrospinal fluid analysis suggestive of aseptic meningitis.

Main Results:

  • Patient symptoms emerged after initiating amiodarone therapy.
  • Cerebrospinal fluid analysis findings were consistent with aseptic meningitis.
  • Symptoms showed rapid resolution upon discontinuation of amiodarone.

Conclusions:

  • Amiodarone should be considered a potential cause of drug-induced aseptic meningitis.
  • This case expands the spectrum of known adverse drug reactions associated with amiodarone.
  • Prompt recognition and withdrawal of amiodarone are crucial for managing amiodarone-induced aseptic meningitis.