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Related Experiment Video

Updated: May 10, 2026

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

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Published on: November 14, 2018

Histamine Originating from the BNST Modulates Corticostriatal Synaptic Transmission during Early Postnatal

Ricardo Márquez-Gómez^1,2, Yasmin Cras³, Brenna Parke⁴

¹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|May 8, 2026

Summary

Histamine, a brain neuromodulator, is crucial for development. Researchers identified the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) as a novel source of histamine in the developing striatum.

Keywords:

BNST cortex development histamine neuromodulation spiny projection neuron striatum

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Published on: January 20, 2015

Area of Science:

Neuroscience
Developmental Neuroscience
Neuropharmacology

Background:

Histamine regulates critical brain functions, but its sources in the developing striatum are unclear due to sparse innervation.
Understanding histamine's sources is vital for deciphering its role in neurological and neurodevelopmental disorders.

Purpose of the Study:

To investigate the sources of histamine in the developing mouse striatum during the second postnatal week.
To determine if the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) serves as an extrastriatal source of histamine.

Main Methods:

Patch-clamp recording and optogenetic stimulation in brain slices.
Immunohistochemistry for histamine.
Fast scan cyclic voltammetry and fluorescent histamine sensors.
Electrical stimulation of the ovBNST.

Main Results:

Histamine modulates developing D1/D2 striatal spiny projection neurons (SPNs) and synaptic transmission.
Immunohistochemistry identified the ovBNST as densely innervated by histaminergic axons.
Electrical stimulation of the ovBNST released detectable histamine in the striatum.
ovBNST stimulation modulated excitatory synaptic transmission via histamine H3 receptors.

Conclusions:

The ovBNST is an extrastriatal source of histamine during early brain development.
Histamine acts as a paracrine neuromodulator, crossing anatomical boundaries in the developing brain.