Pyruvylation: a new post-translational modification mechanism
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Updated: May 10, 2026

Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
Published on: February 27, 2020
1Department of Toxicology, State Key Laboratory of Natural and Biomimetic Drugs, School of Public Health, Peking University, Beijing, China.
Abstract:
In a recent Cell study, Zuo et al. identified pyruvylation as a previously unrecognized post-translational modification (PTM) mechanism that suppresses type I interferon signaling and antiviral immunity through pyruvate-mediated pyruvylation of the signal transducer and activator of transcription 1 protein. This expands the repertoire of metabolite-controlled PTMs and highlights pyruvylation as a promising antiviral therapeutic approach.
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