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Published on: May 10, 2024
Risk factors for thrombosis in eosinophilia: A case-control study
Dongfeng Liang1,2, Zhengyuan Hu1, Wencheng Sun3
1Department of Rheumatology and Immunology, the First Medical Center of Chinese PLA General Hospital, 100853, Beijing, China.
Scientific Reports
|May 8, 2026
Summary
Peripheral neuropathy may increase the risk of thrombosis in patients with eosinophilia. This finding is crucial for identifying at-risk individuals and improving their management strategies.
Area of Science:
- Hematology
- Neurology
- Clinical Medicine
Background:
- Sustained eosinophilia is a potential indicator of serious health issues.
- Eosinophilia is associated with an elevated risk of thrombosis.
- Identifying thrombosis risk factors in eosinophilia is critical for patient management.
Purpose of the Study:
- To investigate potential risk factors for thrombosis in patients with eosinophilia.
- To identify specific clinical characteristics associated with thrombosis in this patient group.
Main Methods:
- A case-control study design was employed.
- Patients with an absolute eosinophil count ≥ 500 cells/µL were included.
- Multivariable logistic regression analysis was used to identify risk factors.
Main Results:
- Out of 88 patients, 40 (45.5%) experienced thrombosis.
- Peripheral neuropathy was significantly more prevalent in patients with thrombosis (35.0% vs. 12.5%, p=0.012).
- Peripheral neuropathy was identified as an independent risk factor for thrombosis (OR: 3.39; 95% CI: 1.02-11.47; p=0.045).
Conclusions:
- Peripheral neuropathy may serve as a significant risk factor for thrombosis in eosinophilia.
- Early identification of peripheral neuropathy in eosinophilic patients can aid in thrombosis risk assessment.
- This research provides valuable insights for the clinical management of patients with eosinophilia and thrombosis risk.
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