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Circulating Biomarker Results From a Phase 2 Study of Seralutinib in Pulmonary Arterial Hypertension

Robin Osterhout1, Athénaïs Boucly2, Raymond L Benza3

  • 1Gossamer Bio, Inc, San Diego, CA, United States.

American Journal of Respiratory and Critical Care Medicine
|May 8, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
HemodynamicsInflammation MediatorsMolecular Mechanisms of Pharmacological ActionTyrosine Kinase InhibitorVascular Remodeling

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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