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KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation
Yang Qin1,2,3, Jiani Zhang2, Yanwen Zhang2
1Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Communications Biology
|May 8, 2026
Summary
KIAA1199 protein levels increase in sepsis patients and worsen acute lung injury (ALI) in mice. Reducing KIAA1199 improves survival by inhibiting complement activation, suggesting it as a therapeutic target for sepsis-induced ALI.
Area of Science:
- Immunology
- Cell Biology
- Pulmonology
Background:
- Sepsis-induced acute lung injury (ALI) is a severe condition with high mortality.
- KIAA1199 (CEMIP) is implicated in bacterial infections, but its role in sepsis-ALI is unknown.
- Elevated KIAA1199 is observed in sepsis patients and septic mouse lungs, particularly in alveolar epithelial Type II (AT2) cells.
Purpose of the Study:
- To investigate the role of KIAA1199 in sepsis-induced ALI.
- To explore the underlying mechanisms of KIAA1199's action in ALI.
- To assess KIAA1199 as a potential therapeutic target for sepsis-ALI.
Main Methods:
- Measured serum KIAA1199 levels and correlated with SOFA scores in sepsis patients.
- Generated AT2-specific KIAA1199 knockout mice.
- Utilized LPS-induced ALI model in mice.
- Performed transcriptomic analysis and functional validation.
Main Results:
- Serum KIAA1199 levels were elevated in sepsis patients and correlated with SOFA scores.
- KIAA1199 knockout mice showed improved survival, reduced lung injury, and lower proinflammatory cytokines.
- KIAA1199 was found to promote pulmonary complement activation by downregulating complement factor H (CFH).
- KIAA1199 enhances CFH degradation via p53 ubiquitination.
Conclusions:
- KIAA1199 exacerbates sepsis-induced ALI by promoting local complement activation.
- Suppression of CFH by KIAA1199 is a key mechanism in sepsis-ALI pathogenesis.
- KIAA1199 represents a potential therapeutic target for sepsis-induced ALI.
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