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RING finger E3 ubiquitin ligases: novel therapeutic opportunities in melanoma

Ji-Fang Zhang1, Long-Tian Li1, Yue-Ying Yang1

  • 1Department of Pharmacy, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Shenyang, 110004, People's Republic of China.

Cellular & Molecular Biology Letters
|May 8, 2026
PubMed

Insights

Novel therapies targeting RING finger E3 ubiquitin ligases (RNFs) offer new hope for melanoma treatment. This review explores RNF functions and therapeutic strategies, including PROTACs, for overcoming drug resistance in melanoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Melanoma is an aggressive cancer known for developing resistance to current therapies.
  • RING finger E3 ubiquitin ligases (RNFs) are critical regulators in the ubiquitin-proteasome system and melanoma development.
  • Novel therapeutic targets are urgently needed to combat melanoma drug resistance.

Purpose of the Study:

  • To analyze the structural and functional characteristics of RNFs in melanoma.
  • To compare the distinct mechanisms of action among different RNFs.
  • To evaluate emerging therapeutic strategies targeting RNFs for melanoma treatment.

Main Methods:

  • Review of existing literature on RNF structure, function, and role in melanoma.
  • Systematic evaluation of RNF-targeted therapeutic approaches.
  • Exploration of computer-aided drug design for RNFs.

Main Results:

  • RNFs orchestrate diverse pathways crucial for melanoma progression.
  • Various RNFs exhibit distinct functional roles and mechanisms.
  • Small-molecule drugs, PROTACs, and molecular glues show promise for RNF-targeted therapy.

Conclusions:

  • RNF-targeted therapies represent a promising avenue for precise melanoma treatment.
  • Combining RNF-targeted therapy with existing treatments may enhance efficacy.
  • Further research and drug development targeting RNFs are significant for clinical application.
Keywords:
MelanomaPROTACRNFsUbiquitination

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