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Updated: May 11, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Lactate abnormalities during intravenous linezolid therapy in hospitalized children: a brief report

Taha Ikram Ozsumbul1, Osman Oguz Demir2, Kubra Aykac2

  • 1Department of Pediatrics, Hacettepe University, Ankara, Turkey.

European Journal of Pediatrics
|May 9, 2026
PubMed

Insights

Linezolid treatment in children frequently causes lactate abnormalities, including hyperlactatemia and lactic acidosis. Younger children and those with complex conditions are more susceptible, requiring careful monitoring.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Pharmacology
  • Biochemistry

Background:

  • Linezolid is a critical antibiotic for severe gram-positive infections in children.
  • Limited data exist on linezolid's metabolic adverse effects in pediatric populations.
  • Lactate abnormalities are a known potential side effect of linezolid.

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