Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Attenuated conditioned taste aversion for sucrose in female mice with a history of chronic low-dose ethanol exposure.

bioRxiv : the preprint server for biology·2026

Same author

Chronic neuropathic pain alters reversal learning and prefrontal cortex activation without generalized deficits in reward-related behavior.

Behavioural brain research·2026

Same author

Chronic neuropathic pain alters reversal learning and prefrontal cortex activation without generalized deficits in reward-related behavior.

bioRxiv : the preprint server for biology·2026

Same author

Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.

Alcohol, clinical & experimental research·2026

Same author

Subcellular interactions of neuropeptide Y and corticotropin-releasing factor in the central nucleus of the amygdala in the mouse.

Neuroscience·2026

Same author

CA inhibitor 1 treatment has only transient effects on estrous cyclicity in mice.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: May 11, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

CA Inhibitor 1 Treatment Does Not Affect Estrous Cyclicity in Mice.

Laura L Giacometti¹, Donna Mae Dalere², Bupe Lwamba²

¹Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA, 19102, USA. llk34@drexel.edu.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology

|May 9, 2026

Summary

Long-acting pre-exposure prophylaxis (PrEP) like lenacapavir may improve HIV prevention adherence in women. This study found no impact on the estrous cycle in mice, suggesting lenacapavir may not disrupt menstrual cycles.

Keywords:

Astrocytes Estrous cycle MPOA Pre-exposure prophylaxis

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Related Experiment Videos

Last Updated: May 11, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Area of Science:

Virology
Endocrinology
Neuroscience

Background:

45% of new global HIV infections occur in women and girls.
Adherence to pre-exposure prophylaxis (PrEP) is a challenge, especially for women.
Long-acting PrEP, such as lenacapavir, offers potential for improved adherence.

Purpose of the Study:

To model the effect of lenacapavir administration on estrous cyclicity in female mice.
To investigate potential impacts of lenacapavir on the medial preoptic area (mPOA), a key regulator of reproductive cycles.

Main Methods:

Adult female C57Bl/6J mice were injected with a capsid (CA) inhibitor, an analog of lenacapavir.
Estrous cyclicity was assessed following injection.
Astrocyte immunoreactivity and cellular activity in the mPOA were evaluated.

Main Results:

Administration of the CA inhibitor did not alter the estrous cycle.
The CA inhibitor did not affect astrocyte immunoreactivity or chronic cellular activity in the mPOA.
These findings suggest lenacapavir may not disrupt reproductive cyclicity.

Conclusions:

Lenacapavir, a long-acting PrEP, did not impact estrous cyclicity in a mouse model.
The drug did not affect key neural regulators of the reproductive cycle.
Further research is warranted to confirm these findings regarding lenacapavir's impact on the menstrual cycle in women, potentially improving PrEP adherence.