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Published on: November 9, 2017
Association between irritable bowel syndrome and Guillain-Barré syndrome-related immune-mediated peripheral
Youngoh Bae1, Miyoung Jang2, Kwan-Young Bak3
1Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea; Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Background:
Irritable bowel syndrome (IBS) is recognized as a systemic disorder involving gut-brain-immune axis dysregulation, but its long-term association with immune-mediated peripheral neuropathies, including Guillain-Barré syndrome (GBS), is unclear.
Methods:
We conducted a nationwide retrospective cohort study using the Korean National Health Insurance database, including approximately 2 million adults from 2012 to 2023. Incident IBS cases were identified after a 3-year washout period and matched 1:2 with controls by age, sex, and health examination year. Primary outcomes were GBS immune-mediated peripheral neuropathies and GBS and related immune-mediated peripheral neuropathies defined by ICD-10 codes; classic GBS was a secondary outcome. Cox proportional hazards models were applied.
Results:
Among 141,781 patients with IBS and matched controls, IBS was associated with increased risk of the primary outcomes (incidence rate ratio, 1.57; 95% CI, 1.48-1.66). In fully adjusted models, IBS remained associated with GBS immune-mediated peripheral neuropathies (adjusted HR, 1.58; 95% CI, 1.44-1.73) and GBS and related immune-mediated peripheral neuropathies (adjusted HR, 1.50; 95% CI, 1.37-1.65), but not with classic GBS (adjusted HR, 1.25; 95% CI, 0.55-2.87).
Conclusions:
IBS was associated with increased long-term risk of GBS spectrum immune-mediated peripheral neuropathies, suggesting a potential association with systemic immune-related condition.
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