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NSCLC: Five trials to watch

Wei-Chi Luo1, Shu-Xin Zhong1, Si-Yang Maggie Liu1

  • 1Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Med (New York, N.Y.)
|May 9, 2026
PubMed

Insights

Advances in circulating tumor DNA (ctDNA) and novel therapies like KRAS G12D inhibitors offer new hope for managing non-small cell lung cancer (NSCLC) as a chronic condition. Clinical trials are exploring these innovations to improve patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Clinical Trials

Background:

  • Non-small cell lung cancer (NSCLC) remains a significant challenge, despite progress in targeted therapy and immunotherapy.
  • Current treatment paradigms do not consistently manage NSCLC as a chronic disease.

Purpose of the Study:

  • To review emerging strategies and clinical trials aimed at transforming NSCLC management.
  • To highlight the potential of ctDNA/MRD-guided adaptive treatment and novel therapeutic agents.

Main Methods:

  • Review of recent advancements in NSCLC treatment.
  • Identification of key emerging therapeutic classes: KRAS G12D inhibitors, TROP2-ADCs, and PD-1/VEGF bispecific antibodies.
  • Analysis of five pivotal clinical trials influencing NSCLC care.

Main Results:

  • Circulating tumor DNA (ctDNA) and molecular residual disease (MRD) monitoring enable adaptive treatment strategies.
  • Novel agents show promise in overcoming treatment resistance and improving efficacy.
  • Emerging clinical trials are poised to significantly impact precision treatment for NSCLC.

Conclusions:

  • The integration of ctDNA/MRD-guided therapy and novel agents represents a paradigm shift towards chronic NSCLC management.
  • Ongoing clinical trials are critical for validating these advancements and realizing the vision of long-term disease control.

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