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Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET

Meng Zhang1, Cristhian Cañari-Chumpitaz2, Jianfang Liu3

  • 1California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.

Molecular Cell
|May 9, 2026
PubMed

Keywords:
DNA supercoilingRNA polymeraseapical binding localizationconvergent transcriptioncryo-electron tomographydCas9divergent transcriptiontopoisomerasetorsional blocktwin supercoiling domains

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