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Updated: May 11, 2026
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In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion
Published on: February 9, 2024
Developmental electrophysiological changes in mouse mesencephalic trigeminal neurons.
1Department of Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan; Department of Physiology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8650, Japan.
Neuroscience Letters
|May 9, 2026
Summary
Postnatal development diversifies firing patterns in mesencephalic trigeminal (MesV) neurons. Their membrane properties mature, enhancing electrical signaling and input integration.
Area of Science:
- Neuroscience
- Developmental Biology
- Electrophysiology
Background:
- The mesencephalic trigeminal (MesV) nucleus plays a crucial role in proprioception.
- Understanding the postnatal maturation of MesV neurons is essential for grasping sensory development.
Purpose of the Study:
- To investigate the electrophysiological maturation of MesV neurons during postnatal development.
- To characterize changes in firing patterns, intrinsic membrane properties, membrane resonance, and inward-rectifying currents.
Main Methods:
- Electrophysiological recordings were performed on MesV neurons at different postnatal ages (P7, P14, P21).
- Analysis included firing patterns, resting membrane potential, input resistance, membrane resonance, and inward-rectifying currents.
Main Results:
- MesV neurons showed a developmental shift in firing modes from predominantly phasic to increased tonic firing.
- Input resistance decreased, while membrane resonance frequency increased, indicating enhanced frequency selectivity.
- Inward rectification strengthened, with faster sag responses and increased current density.
Conclusions:
- MesV neurons exhibit coordinated maturation of passive and active membrane properties during postnatal development.
- These maturational changes support improved neuronal excitability regulation and synaptic input integration.
