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Updated: May 11, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Unveiling NDRGs as potential modulators of insulin signaling and insulin resistance in the central nervous system
Atreyi Mukherjee1, Chinmoy Sankar Dey1
1School of Biological Sciences, Indian Institute of Technology-Delhi, Hauz Khas, New Delhi, 110016, India.
Abstract:
The N-myc downstream-regulated gene (NDRG) family comprises four proteins (NDRG1-4) that lack intrinsic catalytic activity and participate in diverse cellular processes, including differentiation, stress responses, and metabolic regulation. Although NDRGs have been studied primarily in the context of development and cancer, emerging evidence indicates that they both influence components of the canonical insulin signaling pathway and are regulated by insulin. NDRGs are highly expressed in nervous tissue, where insulin signaling is essential for neuronal function and brain metabolism. This mini-review summarizes current knowledge on NDRG function in the nervous system, with emphasis on their links to insulin signaling and insulin-resistance.
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