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Updated: May 11, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

From obesity to cardiovascular disease: pathological basis and clinical implications

Matteo Nardin1, Roxana Mehran2, Angelo Oliva2

  • 1Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, Milan, Italy; Internal Medicine, Department of Medicine, ASST Spedali Civili di Brescia, Piazzale Spedali Civili 1, Brescia, Italy.

The American Journal of Medicine
|May 9, 2026
PubMed

Insights

Obesity significantly impacts cardiovascular health, increasing risks for various conditions. While new therapies offer benefits, personalized strategies are crucial for managing obesity-related heart disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Obesity is a global health crisis with severe cardiovascular consequences.
  • Excess adiposity drives atherosclerosis, hypertension, heart failure, and stroke via complex mechanisms.
  • Dysfunctional adipose tissue, including epicardial fat, promotes inflammation and cardiac remodeling.

Purpose of the Study:

  • To review the cardiovascular implications of obesity.
  • To highlight the mechanisms linking obesity to cardiovascular disease.
  • To discuss current and future therapeutic strategies.

Main Methods:

  • Literature review of obesity and cardiovascular disease.
  • Analysis of mechanisms including inflammation, insulin resistance, and neurohormonal activation.
  • Evaluation of recent therapeutic advances, such as incretin therapies.

Main Results:

  • Obesity is strongly linked to earlier and more severe cardiovascular events.
  • Mechanisms include adipose tissue dysfunction, chronic inflammation, and endothelial impairment.
  • Incretin therapies show promise for weight loss and metabolic improvement.

Conclusions:

  • Integrated precision-medicine and public-health approaches are needed.
  • Addressing obesity phenotyping and risk stratification is essential.
  • Reducing the obesity-related cardiovascular burden requires multifaceted strategies.

Keywords:
Cardiovascular diseaseObesityPathophysiologyTreatment

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