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Published on: April 18, 2025

Tripartite motif-containing 67 promotes progression of hepatocellular carcinoma by regulating MAPK signaling pathway

Zhuang Zhou1, Shi-Yi Zhang1, Ying-Song Jiang1

  • 1Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|May 9, 2026
PubMed
Abstract

Insights

Tripartite motif-containing 67 (TRIM67) promotes hepatocellular carcinoma (HCC) progression by activating the MAPK/ERK1/2 pathway. This finding suggests TRIM67 as a potential therapeutic target for HCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Hepatocellular carcinoma (HCC) presents a growing health challenge with complex management.
  • Identifying novel biological targets is crucial for developing new HCC therapies.

Purpose of the Study:

  • To investigate the role of tripartite motif-containing 67 (TRIM67) in hepatocellular carcinoma (HCC).
  • To explore TRIM67 as a potential therapeutic target for HCC.

Main Methods:

  • High-throughput sequencing identified TRIM67 as a potential HCC target.
  • TRIM67 expression, proliferation, migration, and apoptosis were assessed in HCC tissues and cell lines.
  • The involvement of the MAPK/ERK1/2 signaling pathway was analyzed.

Main Results:

  • TRIM67 expression was significantly elevated in HCC tissues and cell lines.
  • Increased TRIM67 expression promoted HCC cell proliferation and migration.
  • TRIM67 activation of MAPK/ERK1/2 inhibited apoptosis.

Conclusions:

  • TRIM67 promotes HCC progression through MAPK/ERK1/2 pathway activation.
  • TRIM67 represents a promising biological target for HCC treatment.
Keywords:
Hepatocellular carcinomaMAPK/ERK1/2 signaling pathwayTripartite motif-containing 67

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