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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
An evidence-fused neutrosophic framework for uncertainty-aware treatment selection
Mukesh Mann1, Rakesh P Badoni2, Preeti Narooka3
1Department of Computer Science and Engineering, Indian Institute of Information Technology, Sonepat, Haryana, 131001, India. mukesh.maan@iiitsonepat.ac.in.
This study introduces a novel decision-support framework using Neutrosophic Logic, Dempster-Shafer Theory (DST), and Interval-Valued Fuzzy Sets (IVFS) to improve healthcare treatment selection amidst uncertainty and conflicting expert opinions.
Area of Science:
- Decision Analysis
- Healthcare Management
- Uncertainty Quantification
Background:
- Healthcare decision-making faces challenges with incomplete data, conflicting expert opinions, and variability.
- Conventional Multi-Criteria Decision Making (MCDM) methods struggle with vagueness, indeterminacy, and inter-expert conflict.
- Existing neutrosophic approaches lack mechanisms for resolving expert conflicts before ranking.
Purpose of the Study:
- To present an integrated decision-support framework for healthcare treatment selection.
- To address limitations of existing methods in handling uncertainty and conflicting expert judgments.
- To provide a robust and scalable tool for complex healthcare environments.
Main Methods:
- Utilizes Neutrosophic Logic for truth, indeterminacy, and falsity.
- Employs Interval-Valued Fuzzy Sets (IVFS) to capture data variability.
- Integrates Dempster-Shafer Theory (DST) for evidence-theoretic fusion of expert opinions.
- Applies an extended Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) for ranking.
Main Results:
- The framework transforms neutrosophic evaluations into interval-valued fuzzy representations.
- DST systematically fuses expert judgment, avoiding premature consensus.
- Extended TOPSIS generates belief-weighted neutrosophic score rankings.
- Sensitivity analysis and Monte Carlo simulations demonstrate ranking stability and robustness under uncertainty.
Conclusions:
- The proposed framework offers an uncertainty-aware decision-support tool for healthcare.
- It provides interpretable treatment prioritization, handling incomplete data and conflicting opinions.
- The approach is scalable and shows robustness, requiring further validation with real clinical data.
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