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Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...
Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy
09:20

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy

Published on: October 4, 2010

Cellular mechanometabolism: stimuli and implications.

Ismael Ortiz1, Santiago Lopez1, Raghu Vamsi Kondapaneni1

  • 1Department of Bioengineering, Rice University, Houston, TX, USA.

EMBO Reports
|May 9, 2026
PubMed
Summary
This summary is machine-generated.

Mechanical cues from the microenvironment critically influence cellular metabolism and cell behaviors like proliferation. Understanding mechanometabolism is key for tissue function, disease progression, and developing new therapies.

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Live Cell Imaging during Mechanical Stretch
07:42

Live Cell Imaging during Mechanical Stretch

Published on: August 19, 2015

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Last Updated: May 11, 2026

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy
09:20

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy

Published on: October 4, 2010

Live Cell Imaging during Mechanical Stretch
07:42

Live Cell Imaging during Mechanical Stretch

Published on: August 19, 2015

Area of Science:

  • Cell Biology
  • Biophysics
  • Biochemistry

Background:

  • Cellular metabolism is influenced by chemical cues.
  • Mechanical cues from the microenvironment are increasingly recognized as critical regulators of intracellular metabolic pathways.
  • These mechanical signals impact fundamental cell behaviors such as proliferation and migration.

Purpose of the Study:

  • To review recent findings on the role of mechanical cues in cellular metabolism.
  • To discuss how interactions with the extracellular matrix (ECM) and physical forces affect cellular energy production.
  • To highlight the implications of mechanometabolism in physiological and pathological conditions.

Main Methods:

  • Literature review of recent research.
  • Analysis of studies investigating cell-ECM interactions.
  • Examination of the effects of mechanical forces (shear, tension, compression) on cellular metabolism.

Main Results:

  • Mechanical cues from the ECM and cell-cell interactions significantly alter cellular metabolic pathways.
  • Physical forces directly impact cellular energy requirements and production.
  • Mechanometabolism plays a crucial role in maintaining physiological homeostasis and influencing pathological states.

Conclusions:

  • Mechanical forces are critical regulators of cellular metabolism, impacting cell behavior.
  • Understanding mechanometabolism is vital for comprehending tissue function and disease.
  • Further research into mechanometabolism holds potential for novel therapeutic strategies.