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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Video

Updated: May 12, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

Culture-Negative Infective Endocarditis Presenting as ANCA-Positive Glomerulonephritis.

Mohammad Eshaq Kyhan1, Adam M Bressler2

  • 1Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GA, USA.

The American Journal of Case Reports
|May 10, 2026
PubMed
Summary

Bartonella endocarditis can mimic ANCA-associated glomerulonephritis, leading to misdiagnosis. Early recognition of occult Bartonella infection in patients with negative cultures and positive ANCA is crucial for appropriate treatment and preventing organ damage.

Related Experiment Videos

Last Updated: May 12, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Cardiology

Background:

  • Infective endocarditis (IE) diagnosis is difficult with negative blood cultures and nonspecific symptoms.
  • Bartonella species cause culture-negative IE and immune-mediated complications like glomerulonephritis, mimicking ANCA-associated glomerulonephritis.
  • A 25-year-old male presented with symptoms suggestive of glomerulonephritis and positive ANCA serologies.

Purpose of the Study:

  • To highlight Bartonella endocarditis as a mimic of ANCA-associated glomerulonephritis.
  • To emphasize the importance of considering occult infections in culture-negative endocarditis.
  • To underscore the need for early diagnosis and targeted therapy in suspected IE.

Main Methods:

  • Case report of a patient with suspected ANCA-associated glomerulonephritis.
  • Inclusion of clinical presentation, laboratory findings, kidney biopsy results, and serological testing for Bartonella.
  • Treatment with doxycycline and rifampin.

Main Results:

  • Kidney biopsy showed C3-dominant immune complex deposition, atypical for pauci-immune ANCA disease.
  • High Bartonella henselae IgM and IgG titers confirmed the diagnosis.
  • Patient met criteria for possible infective endocarditis under 2023 Duke-ISCVID criteria.
  • Treatment resulted in clinical and laboratory improvement.

Conclusions:

  • Bartonella endocarditis can closely mimic ANCA-associated and rapidly progressive glomerulonephritis.
  • Occult infection should be considered in patients with systemic symptoms, positive ANCA, and negative cultures, especially those at high risk for IE.
  • Thorough exposure history and early recognition of Bartonella infection are vital to prevent irreversible organ damage and avoid unnecessary immunosuppression.