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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

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From Structure to Function: COX-Selective Anti-Inflammatory Activity of Cu(II) and Zn(II) Hydrazone Complexes

Ram Nayan Gautam1, Riya Kumari1, Diptee Mitra2

  • 1Department of Chemistry, Banaras Hindu University, Varanasi, India.

Chembiochem : a European Journal of Chemical Biology
|May 10, 2026
PubMed

Keywords:
anti‐inflammatory activitycyclooxygenase inhibitionhydrazone‐based ligands

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Structural Isomerism

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Metal-Ligand Bonds

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
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