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Updated: May 12, 2026

Bridging the Bio-Electronic Interface with Biofabrication
16:38

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Published on: June 6, 2012

Field‑Programmable Biofunctional Films: From Assisted Fabrication to Integrated Diagnostic-Therapeutic Devices.

Xi Wang1, Yi Chen1,2,3, Yuhan Liu1

  • 1State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, China.

Small (Weinheim an Der Bergstrasse, Germany)
|May 10, 2026
PubMed
Summary
This summary is machine-generated.

Field-programmable biofunctional films (FPBFs) offer programmable, adaptive responses to physical stimuli for advanced diagnostics and therapeutics. These biointerfaces integrate materials science and medicine for precision healthcare applications.

Keywords:
field‐programmable biofunctional filmsintegrated diagnostic‐therapeutic systemsmultimodal biosensingmultiphysical couplingphysical‐field‐assisted fabrication

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Modern biomedical engineering relies on integrating physical fields, functional matter, and medicine.
  • Field-programmable biofunctional films (FPBFs) are emerging biointerfaces with programmable responses to physical stimuli.

Purpose of the Study:

  • To review advances in FPBF fabrication and applications.
  • To highlight the multiphysical-coupling framework of FPBFs for integrated diagnostic-therapeutic functions.
  • To discuss challenges and future directions for FPBFs in adaptive biomedical systems.

Main Methods:

  • Review of single and multiphysical-field-assisted fabrication strategies for FPBFs.
  • Analysis of material composition, structural programmability, and field-induced responsiveness.
  • Exploration of biomedical applications including biosensing, molecular diagnostics, drug release, and targeted therapy.

Main Results:

  • FPBFs demonstrate spatiotemporally controlled, programmable responses to diverse physical fields.
  • Multiphysical coupling in FPBFs enables integrated closed-loop diagnostic-therapeutic functions.
  • FPBFs show promise in biosensing, drug delivery, and targeted therapies, with potential integration into clinical devices.

Conclusions:

  • FPBFs represent a foundation for next-generation adaptive biomedical systems.
  • Synergistic bio-physical coupling is key to realizing programmable, precision healthcare.
  • Further research is needed to address challenges in multifunctional integration, biocompatibility, and clinical translation.