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Related Experiment Video

Updated: May 12, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

ROS-responsive hydrogel for treating pulpitis: Localized immunometabolic regulation by dimethyl itaconate promotes

I-Chen Tsai1, Luhui Cai1, Cheng Tian1

  • 1Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.

Colloids and Surfaces. B, Biointerfaces
|May 10, 2026
PubMed
Summary

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This study developed a novel hydrogel delivering dimethyl itaconate (DMI) to reduce inflammation and oxidative stress in dental pulp stem cells (DPSCs). This approach promotes functional pulp regeneration for vital pulp therapy.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Immunology

Background:

  • Pulpitis causes inflammation and oxidative stress, impairing dental pulp stem cell (DPSC) regeneration.
  • This hinders successful vital pulp therapy, a key dental regenerative treatment.

Purpose of the Study:

  • To develop an immunometabolic strategy using dimethyl itaconate (DMI) and a reactive oxygen species (ROS)-responsive hydrogel.
  • To modulate the inflammatory microenvironment and promote functional pulp regeneration in pulpitis.

Main Methods:

  • DMI was tested for its effects on LPS-induced inflammation and ROS in DPSCs.
  • A dual-crosslinked SADA/CMBA hydrogel was synthesized for localized and sustained DMI delivery.
  • In vitro and in vivo (rat pulpitis model) studies evaluated the hydrogel's efficacy.
Keywords:
Dimethyl itaconateImmunometabolic modulationPulp regenerationPulpitisReactive oxygen species

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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

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Last Updated: May 12, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Main Results:

  • DMI suppressed inflammatory cytokine expression and ROS accumulation in DPSCs.
  • The hydrogel facilitated ROS-triggered DMI release and showed cytocompatibility, anti-inflammatory, and antioxidant effects.
  • In vivo, the DMI-loaded hydrogel reduced pulpal inflammation and promoted reparative dentin formation.

Conclusions:

  • The study presents an immunometabolic and microenvironment-responsive therapeutic design for pulpitis.
  • ROS-adaptive biomaterials show potential for enhancing vital pulp therapy outcomes.