Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

O-GlcNAc transferase couples nutrient availability to synaptic plasticity in paraventricular neurons to regulate satiety.

The Journal of biological chemistry·2026
Same author

A Review of RNA Structure Prediction: Exploring the Potential of Computational Approaches.

IEEE transactions on computational biology and bioinformatics·2025
Same author

Neurophysiological Treatment Effects of Mesdopetam, Pimavanserin and Amantadine in a Rodent Model of Levodopa-Induced Dyskinesia.

The European journal of neuroscience·2025
Same author

The behavioural consequences of dystrophinopathy.

Disease models & mechanisms·2025
Same author

Neurophysiological treatment effects of mesdopetam, pimavanserin and clozapine in a rodent model of Parkinson's disease psychosis.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2024
Same author

<i>In vivo</i> spontaneous activity and coital-evoked inhibition of mouse accessory olfactory bulb output neurons.

iScience·2023
Same journal

Expression of concern: "Effect of perioperative preemptive analgesia on hippocampal GABAA receptor α1/α5 balance in aged mild cognitive impairment rats" [Brain Res. Bull. 237 (2026) 111811].

Brain research bulletin·2026
Same journal

Ubiquitination in ischemic stroke: molecular mechanisms and therapeutic implications.

Brain research bulletin·2026
Same journal

Corrigendum to "Peripheral to central: Exploring the neural, endocrine, and immune pathways of the gut-brain axis in postoperative neurocognitive dysfunction" [Brain Res. Bull. 242 (2026) 111975].

Brain research bulletin·2026
Same journal

GLUT1-driven glycolytic reprogramming in microglia promotes neuroinflammation and cognitive deficits in sepsis-associated encephalopathy.

Brain research bulletin·2026
Same journal

Spinal astrocytes hardly proliferate following peripheral nerve injury: Evidence from adult Aldh1l1-GFP reporter mice.

Brain research bulletin·2026
Same journal

Shared Neural Mechanisms of Trait Mindfulness and Hypnotic Susceptibility: A Scoping Review Toward a Unifying Predictive Coding Framework.

Brain research bulletin·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Anatomical input-output streams within mouse orbitofrontal cortex subdivisions.

Anushree Tripathi1, Luciano Censoni1, Paolo Medini1

  • 1Medical Translational Biology Dept., Medical Faculty, Umeå University, Umeå 90187, Sweden.

Brain Research Bulletin
|May 10, 2026
PubMed
Summary
This summary is machine-generated.

This study maps the mouse orbitofrontal cortex (OFC) circuitry, revealing distinct functional pathways for decision-making and emotional control. Understanding this mouse OFC connectivity aids research into affective disorders.

Keywords:
Input and output tracingInter area connectivityOrbitofrontal cortexQuantitative neuroanatomy

More Related Videos

Miniscope Recording Calcium Signals at Hippocampus of Mice Navigating an Odor Plume
06:21

Miniscope Recording Calcium Signals at Hippocampus of Mice Navigating an Odor Plume

Published on: September 20, 2024

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

Related Experiment Videos

Last Updated: May 12, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Miniscope Recording Calcium Signals at Hippocampus of Mice Navigating an Odor Plume
06:21

Miniscope Recording Calcium Signals at Hippocampus of Mice Navigating an Odor Plume

Published on: September 20, 2024

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Computational Neuroscience

Background:

  • The orbitofrontal cortex (OFC) is crucial for flexible value representation and decision-making.
  • OFC dysfunction is linked to affective disorders.
  • Species differences necessitate detailed mouse OFC connectivity studies for translational research.

Purpose of the Study:

  • To compare the density of retrograde inputs, axonal outputs, and inter-subdivision connectivity within the mouse OFC.
  • To investigate specific subdivisions: medial-orbital (MO), ventral-orbital (VO), (dorso)lateral-orbital (DLO), and agranular insula (AI).
  • To propose a circuit model for emotional reactivity and decision-making.

Main Methods:

  • Retrograde tracing to map inputs and outputs.
  • Analysis of inter-subdivision connectivity.
  • Cluster analysis of input and output distributions.
  • Functional connectivity modeling.

Main Results:

  • VO/LO and MO/DLO showed similar input distributions, distinct from AI.
  • VO targeted sensory areas, while AI targeted the amygdala.
  • Information flow within the OFC is proposed to be from (D)LO to VO, MO, and AI.
  • Distinct reciprocal connections with thalamic, dopaminergic, and serotonergic systems were identified.

Conclusions:

  • A putative model of mouse OFC circuitry is proposed, integrating sensory-motor plans, motivational state, cue-uncertainty, and current goals.
  • This circuit model suggests a role in controlling emotional reactivity and decision-making.
  • The findings enhance our understanding of OFC function and its relevance to affective disorders.