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Updated: May 12, 2026

Use of a Hanging-weight System for Liver Ischemia in Mice
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Published on: August 7, 2012

Cold-induced liver dysfunction drives cardiac damage through a liver-heart axis.

Jing Feng1, Tong Zhao1, Lina Yao1

  • 1State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China; State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, and Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin, 150081, China; Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin, 150081, China.

European Journal of Pharmacology
|May 10, 2026
PubMed
Summary

Cold exposure harms the heart by causing liver injury and metabolic issues. The liver

Keywords:
CVDsCell cycleCold exposureLipid metabolismLiver–heart axis

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Published on: October 27, 2020

Area of Science:

  • Cardiovascular Medicine
  • Hepatology
  • Environmental Health

Background:

  • Cold environments are established risk factors for cardiovascular diseases (CVDs).
  • The liver's role in cold-induced CVD pathogenesis is not well understood.
  • Understanding liver-heart crosstalk is crucial for managing cold-related cardiac conditions.

Purpose of the Study:

  • To investigate the liver's role in cardiac damage in cold regions.
  • To identify mechanisms linking cold exposure, liver dysfunction, and CVD.

Main Methods:

  • Integrated clinical cohort studies, bioinformatic analysis, and animal experiments.
  • Analyzed serum alanine aminotransferase (ALT) levels in cold-exposed populations.
  • Performed transcriptomic analysis on mouse liver tissues and in vitro co-culture experiments.

Main Results:

  • Elevated serum ALT independently predicted heart failure in cold-exposed individuals.
  • Chronic cold exposure induced liver injury, dyslipidemia, and cardiac remodeling in mice.
  • Activated hepatic cell cycle signaling and paracrine factors from hepatocytes contributed to cardiomyocyte injury.

Conclusions:

  • Liver injury is an independent risk factor for CVDs in cold regions.
  • Chronic cold stress disrupts liver metabolism and activates cell cycle signaling.
  • Liver-heart crosstalk mediated by metabolic and signaling pathways contributes to cold-induced cardiac injury.