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Related Experiment Video

Updated: May 12, 2026

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

Published on: January 20, 2023

[Adult pulmonary blastoma:a case report].

N Zhang¹, W L Zhang¹, Y N Ge¹

¹Department of Geriatric Respiratory and Sleep Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases

|May 10, 2026

Summary

Pulmonary blastoma, a rare lung cancer, was successfully treated with surgery and immunotherapy in a young female. This case highlights its unique features and effective multimodal treatment strategies.

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Last Updated: May 12, 2026

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Published on: February 27, 2026

Area of Science:

Oncology
Thoracic Surgery
Pathology

Background:

Pulmonary blastoma is an exceptionally rare and aggressive primary lung neoplasm.
It presents unique diagnostic challenges due to its biphasic epithelial and mesenchymal components.

Purpose of the Study:

To report a case of pulmonary blastoma in a young adult.
To analyze the clinical, pathological, and immunohistochemical characteristics of this rare tumor.
To discuss optimal treatment strategies and prognosis.

Main Methods:

Case report detailing a 21-year-old female with a right lower lobe lung mass.
Diagnostic workup included PET-CT, biopsy, and detailed histopathological examination.
Immunohistochemistry was performed to characterize tumor components.
Treatment involved neoadjuvant immunochemotherapy, radical surgical resection, and adjuvant immunotherapy.

Main Results:

The tumor measured 8.5 cm and exhibited mixed epithelial (adenocarcinoma-like) and mesenchymal components.
Immunohistochemistry revealed specific markers including AE1/AE3, TTF-1, SALL4, and Ki-67 (40%).
The patient achieved a favorable outcome with the comprehensive treatment regimen.

Conclusions:

Pulmonary blastoma requires careful differentiation from other lung malignancies.
Multimodal therapy, including surgery, chemotherapy, and immunotherapy, is crucial for favorable outcomes.
This case underscores the importance of individualized treatment for rare lung tumors.