Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stigma Profiles and Psychosocial Correlates Among Women with Pelvic Organ Prolapse: A Latent Class Analysis.

International urogynecology journal·2026

Same author

Discrepancies between fall risk and fall awareness in hospitalized elderly patients with cataracts: a cross-sectional study.

Frontiers in medicine·2026

Same author

Influenza vaccine Hesitancy in older adults in China: A latent profile analysis.

Human vaccines & immunotherapeutics·2026

Same author

[Catalytic mechanisms and applications of plastic-degrading enzymes: a review].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2025

Same author

Reproductive concerns in young women with cervical cancer: latent profiles and key influencing factors.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025

Same author

The Role of Skin-to-Skin Contact and Noise Management in Noise-Induced Stress on Breastfeeding Self-Efficacy and Neonatal Cortisol Levels.

Noise & health·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Unlocking Enzyme Discovery: Leveraging Multi-Omics, Machine Learning, and De Novo Design.

Hongming Xia¹, Chunxiu Zhou¹, Baotong Fu¹

¹Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, China.

Methods in Molecular Biology (Clifton, N.J.)

|May 10, 2026

Summary

This summary is machine-generated.

Novel screening strategies like metagenomics and AI are accelerating enzyme discovery, overcoming limitations of traditional methods. These advances enhance enzyme efficiency and stability for industrial applications, including biomass conversion and plastic recycling.

Keywords:

De novo enzyme Enzyme discovery Machine learning Metagenomics Metaproteomics

More Related Videos

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

Related Experiment Videos

Last Updated: May 12, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

Area of Science:

Biochemistry and Biotechnology
Protein Engineering
Bioinformatics

Background:

Enzymes are crucial protein catalysts with broad industrial and healthcare applications.
Natural enzyme limitations and slow traditional discovery methods hinder wider use.
Advances in multi-omics and AI offer new avenues for enzyme discovery and engineering.

Purpose of the Study:

To assess high-throughput enzyme discovery strategies.
To compare the advantages and limitations of various novel approaches.
To discuss the potential of specific enzyme classes in environmental applications.

Main Methods:

Metagenomics and metaproteomics for exploring microbial diversity.
Machine learning for predicting enzyme function and properties.
De novo enzyme design for creating novel biocatalysts.
Comparative analysis of different high-throughput screening techniques.

Main Results:

Novel strategies significantly enhance enzyme catalytic efficiency and stability.
Metagenomics and AI-driven methods offer higher throughput and broader scope than traditional approaches.
Specific enzymes show promise for lignocellulose degradation and plastic waste recycling.

Conclusions:

High-throughput screening methods are revolutionizing enzyme discovery.
AI and multi-omics accelerate the identification and engineering of enzymes with improved characteristics.
Enzymes play a vital role in sustainable industrial processes like biomass conversion and plastic recycling.