Related Experiment Video
Updated: May 12, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Maternal Adverse Childhood Experiences, Postpartum Care Utilisation, and Postpartum Depressive Symptoms
Genevieve G Palazzolo1, Shannah R Mwanda2, Sarah Nechuta1
1College of Health Professions, Department of Public Health, Grand Valley State University, Grand Rapids, Michigan, USA.
Background:
Adverse childhood experiences (ACEs) are known predictors of mental health outcomes later in life. To date, few studies have examined ACEs and postpartum mental health, and data are limited on the role of ACEs in the utilisation of postpartum care, which is important for identifying women at risk of postpartum depression.
Objectives:
We evaluated the associations between ACEs and postpartum depressive symptoms (PDS) and utilisation of postpartum care (maternal postpartum checkup and depression screening).
Methods:
We conducted a serial, cross-sectional study using the Pregnancy Risk Assessment and Monitoring System (PRAMS) data from 2016 to 2022. PRAMS is a population-based surveillance system implemented by state health departments among women who have had a recent live birth. The sample included four jurisdictions with ACE data (n = 23,913). Self-reported outcomes included receipt of a postpartum checkup, being asked about depression during the postpartum visit, and PDS. Logistic regression models accounting for complex survey weighting estimates provided confounder-adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) for the associations of ACEs (individual and score) and outcomes.
Results:
The prevalence of 0, 1, 2-3, or ≥ 4 ACEs was 48.8%, 25.6%, 17.9%, and 7.6%, respectively. The prevalence of PDS was 15.2%. In adjusted models, ACEs were associated with increased prevalence of PDS, with PRs being 1.17 (95% CI 1.03, 1.30), 1.40 (95% CI 1.23, 1.57), and 1.86 (95% CI 1.60-2.13) for 1, 2-3, and ≥ 4 ACEs, respectively. Each individual ACE was associated with increased prevalence of PDS. ACEs were also associated with increased prevalence of no maternal postpartum checkup but were not associated with maternal depression screening.
Conclusions:
In this large population-based study, we found that women with higher ACEs had increased prevalence of maternal PDS. Findings support the need for prenatal screening for ACEs and for providing postpartum support and resources for women with a history of ACEs.
Related Concept Videos
Development of the Oral Microbiota
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Depressive Disorders: MDD and Dysthymia

