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Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
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LINC00240 Knockdown Suppresses the Proliferation, Migration, and Invasion of Ovarian Cancer Cells Through the

Yunjie Tian1, Jianlei Wu2, HaiBo Zhang1

  • 1Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Journal of Cellular and Molecular Medicine
|May 11, 2026
PubMed

Insights

This study reveals that LINC00240 and P4HA2 are overexpressed, while miR-30c-5p is downregulated in ovarian cancer. The LINC00240/miR-30c-5p/P4HA2 axis impacts ovarian cancer progression, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer is a lethal malignancy often diagnosed late.
  • Novel therapeutic strategies are urgently needed.
  • The roles of LINC00240, miR-30c-5p, and P4HA2 in ovarian cancer are investigated.

Purpose of the Study:

  • To investigate the expression and functional roles of LINC00240, miR-30c-5p, and P4HA2 in ovarian cancer.
  • To elucidate the regulatory axis involving these molecules in ovarian cancer pathogenesis.
  • To identify potential therapeutic targets for ovarian cancer.

Main Methods:

  • Analysis of public datasets (GSE66957, GEPIA).
  • Quantitative real-time polymerase chain reaction (qRT-PCR) for gene expression.
  • Bioinformatics analysis (TargetScan) and dual-luciferase reporter assays for interaction validation.
  • Functional assays (colony formation, Transwell) to assess cellular effects.

Main Results:

  • LINC00240 and P4HA2 were significantly overexpressed in ovarian cancer.
  • miR-30c-5p was significantly downregulated in ovarian cancer.
  • LINC00240 regulates P4HA2 expression via miR-30c-5p, impacting cancer cell proliferation, migration, and invasion.

Conclusions:

  • The LINC00240/miR-30c-5p/P4HA2 axis plays a crucial role in ovarian cancer malignancy.
  • This axis represents a promising target for novel ovarian cancer therapies.
Keywords:
LINC00240P4HA2miR‐30c‐5povarian cancerproliferation

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