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Enhancing autonomy in PICC placement: The feasibility of single-operator bubble test technique
Ferdinando Longo1, Luigi Maria Remore1, Francesca Claps1
1Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
The Journal of Vascular Access
|May 11, 2026
Summary
A new single-operator bubble test technique allows one clinician to confirm peripherally inserted central catheter (PICC) tip placement using ultrasound. This efficient, radiation-free method improves workflow and is ideal for resource-limited settings.
Area of Science:
- Medical Imaging
- Interventional Cardiology
- Vascular Access
Background:
- Accurate peripherally inserted central catheter (PICC) tip positioning is crucial for function and complication avoidance.
- Intracavitary electrocardiography (IC-ECG) is standard but has limitations.
- The traditional two-operator ultrasound bubble test (CEUS) can be inefficient.
Purpose of the Study:
- To introduce and evaluate a novel single-operator bubble test for PICC tip confirmation.
- To assess the feasibility and reproducibility of this streamlined technique.
Main Methods:
- A single operator performed agitated saline injection and ultrasound assessment using a convex probe manipulated externally through sterile drapes.
- Utilized a single ultrasound system with both linear and convex probes for subcostal cardiac views.
- A preliminary descriptive case series of 10 adult patients was conducted.
Main Results:
- The single-operator technique was feasible and reproducible in all 10 patients.
- Successful real-time visualization of microbubbles in the right atrium was achieved.
- No immediate procedure-related complications were reported.
Conclusions:
- The single-operator bubble test enhances procedural autonomy and efficiency for PICC tip confirmation.
- It offers a practical, safe, and radiation-free alternative, especially in resource-limited environments.
- Requires advanced ultrasound skills and careful infection control measures.

