Discovery and Evaluation of Spirofluorenes Based on Imidazolidinedione as Insecticidal Agent Leads

Eight imidazolidine-2,4-dione derivatives based on spirofluorenes (3-10) have been investigated; these include differences in the aliphatic chain's length and functional groups. Spiro[fluorene-9,4'-imidazolidine]-2',5'-dione 1 was alkylated with different ethyl halo ester to create ethyl 3-(2',5'-dioxospiro[fluorene-9,4'-imidazolidin]-1'-yl)alkanoate 3-6. The corresponding alkanoic acids 7-10 were obtained by hydrolyzing the esters 3-6 with potassium hydroxide in methanol and then acidifying the mixture. Spectral and elemental analysis were employed to regulate the structure and purity of materials 3-10. The findings demonstrated that each product tested exhibited variable levels of insecticidal effective against the larval instars of Spodoptera littoralis. With an LC₅₀ value of 11.68 mg/L against larvae in their second instar, compound 8 was the most effective of all. A range of biological parameters, such as adult longevity, pupal weight, the proportion of normal and deformed pupae, adult emergence, fecundity, and egg hatchability, were employed to assess the latent effects of the prepared materials under examination in an effort to further marginally expand insecticidal materials. The foundation for creating next-generation pest management strategies that address resistance issues and encourage the use of workable chemical remedies is established by this study.