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Updated: May 12, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Mechanochemical NH4Cl-mediated hydrogen-bonding network reconstruction of HFIP: enabling yne-allylic substitutions
Qianzhi Yang1, Xuguang Kong1, Xin Liu1
1Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 443002, Yichang, China. zlh2023@ctgu.edu.cn.
Abstract:
Herein, we report a practical strategy for H-bonding network recombination of Hexafluoroisopropanol (HFIP) enabled by NH4Cl mediated mechanochemical operation, which efficiently facilitates diverse intermolecular yne-allylic substitutions. Mechanistic studies reveal the key synergy between mechanochemical activation and NH4Cl-induced formation of anion-binding HFIP aggregates, which enhance carbocation reactivity and increase system acidity. Notably, stoichiometric HFIP and NH4Cl usage, coupled with facile operation, renders this method highly scalable.
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