NF3 for difluoroamination of tertiary lithium reagents
Hong Xu1, Jin-Hong Lin1,2, Ji-Chang Xiao1
1State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200032 Shanghai, China. jchxiao@sioc.ac.cn.
None:
Difluoroamino (NF2) groups are highly valuable in functional materials-particularly energetic materials-yet efficient and general methods for their direct installation remain largely underdeveloped. Here, we report a mild and practical difluoroamination protocol using nitrogen trifluoride (NF3), an inexpensive and bench-stable gas, as a NF2 source for difluoroamination of tertiary organolithium reagents. This method delivers C-NF2 bonds in high yields (up to 86%) and provides a scalable, safer alternative for incorporating NF2 groups into complex molecular architectures.
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