Related Experiment Video
Updated: May 12, 2026
10:03
Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
Published on: August 15, 2025
Fabricating Blackened Jujube Polysaccharide-Zn (II) Complex to Enhance its Anti-Inflammatory Effect: Structural
Li Zhang1, Xi Che1, Xin Zhang1
1College of Food Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.
Journal of Food Science
|May 11, 2026
Summary
Blackened jujube polysaccharides chelated with zinc (BP-Zn) show potent anti-inflammatory effects. This novel complex stabilizes polysaccharides, restores gut health, and modulates microbiota, offering potential as a natural therapeutic agent.
Area of Science:
- Pharmacology
- Biochemistry
- Materials Science
Background:
- Blackened jujube polysaccharides (BP) possess pharmacological activities.
- Chelating BP with zinc ions (Zn II) can enhance biological functions.
- Developing novel polysaccharide-Zn complexes is of interest for therapeutic applications.
Purpose of the Study:
- To synthesize and characterize a novel polysaccharide-Zn (II) complex from blackened jujube (BP-Zn).
- To evaluate the anti-inflammatory effects of BP-Zn in a dextran sulfate sodium (DSS)-induced colitis model.
- To investigate the impact of BP-Zn on gut microbiota and metabolic pathways.
Main Methods:
- Synthesis and characterization of the BP-Zn complex.
- Induction of colitis using DSS in a mouse model.
- Assessment of anti-inflammatory effects, including body weight, thymus index, and intestinal barrier integrity.
- Microbiome and metabolomic profiling.
Main Results:
- The BP-Zn complex was successfully synthesized, with -OH and -COOH groups interacting with Zn II.
- BP-Zn significantly reduced body weight loss, increased thymus index, and restored intestinal barrier integrity in DSS-induced colitis.
- BP-Zn modulated gut microbiota composition, promoting beneficial bacteria and inhibiting pathogens.
- Metabolomic analysis revealed that BP-Zn influenced amino acid and flavonoid metabolism pathways related to inflammation.
Conclusions:
- Zinc chelation enhances the structural stability and properties of blackened jujube polysaccharides.
- The BP-Zn complex exhibits significant anti-inflammatory effects in a colitis model.
- BP-Zn demonstrates potential as a natural anti-inflammatory agent by modulating gut microbiota and metabolic pathways.
