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Related Experiment Video

Updated: May 12, 2026

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

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Photodistributed Hyperpigmentation in a Chronic Kratom User: Histologic and Elemental Characterization.

Aubrey Nicole Montebello1, Michael R Lewin-Smith2, Liesl Grenier3

  • 1SAUSHEC, Wilford Hall Ambulatory Surgical Center, Lackland, Texas, USA.

Journal of Cutaneous Pathology
|May 11, 2026
PubMed
Summary

Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Chronic kratom use can cause unusual skin discoloration, specifically photodistributed dyspigmentation. This case highlights a rare cutaneous side effect of kratom, involving pigment analysis.

Area of Science:

  • Dermatology
  • Toxicology
  • Pharmacology

Background:

  • Kratom (Mitragyna speciosa) is a plant-derived supplement gaining popularity for pain and mood management.
  • Its use is associated with opioid-like effects, but cutaneous side effects are seldom reported.
  • Systemic side effects of kratom are documented, yet skin manifestations remain under-investigated.

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