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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.

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Related Experiment Video

Updated: May 12, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

GEAR Genomics: a user-friendly, open-source web platform enabling interactive genomic analysis for molecular

Andreas Untergasser1, Markus Hsi-Yang Fritz1, Vladimir Benes1

  • 1European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg 69117, Germany.

Nucleic Acids Research
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

GEAR is a free, web-based genomics framework simplifying molecular biology tasks. This platform offers interactive tools for various analyses, enhancing accessibility and reproducibility for researchers without bioinformatics expertise.

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Last Updated: May 12, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

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Published on: August 15, 2019

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Introductory Analysis and Validation of CUT&RUN Sequencing Data

Published on: December 13, 2024

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Routine genomics and molecular biology tasks often rely on complex, proprietary software.
  • This heterogeneity limits accessibility, reproducibility, and ease of use in laboratory settings.

Purpose of the Study:

  • To introduce GEAR, a unified, web-based genomics framework.
  • To provide accessible, interactive tools for common molecular biology and genomics analyses directly in the browser.
  • To eliminate the need for software installation, registration, or licensing, catering to users without prior bioinformatics expertise.

Main Methods:

  • Developed a web-based platform integrating established algorithms with modern web technologies.
  • Created a collection of lightweight, interactive applications for diverse genomics tasks.
  • Ensured the framework is open-source and extendible.

Main Results:

  • GEAR offers a suite of tools for Sanger chromatogram visualization, alignment, variant detection, primer design, in-silico PCR, qPCR analysis, barcode handling, sequencing quality control, DNA manipulation, and sequence alignment visualization.
  • The platform requires no installation or registration, facilitating rapid and intuitive use.
  • All code is free and open-source.

Conclusions:

  • GEAR serves as an integrated, user-friendly genomics web server.
  • It consolidates diverse bioinformatics tools into a single, coherent framework.
  • The platform enhances interactivity, reproducibility, and ease of use for routine and exploratory genomic analyses.